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KMID : 0895820180280030055
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Journal of Oriental Rehabilitation Medicine
2018 Volume.28 No. 3 p.55 ~ p.66
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A Systematic Review of Bee Venom Acupuncture for Ankle Sprain
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Gu Ji-Hyang
Lee Ok-Jin
Jo Dong-Chan
Lee Eun-Jung
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Abstract
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Objectives: To evaluate the evidence supporting the effectiveness of bee venom acupuncture for ankle sprain.
Methods: We conducted search across 11 electronic databases (Pubmed, EMBASE, Cochrane CENTRAL [CENTRAL], KoreaMed, Kmbase, Koreanstudies Information Service System [KISS], National Digital Science Library [NDSL], Korea Institute of Science and Technology Information [KISTI], China National Knowledge Infrastructure [CNKI], Wanfang and Chinese Scientific Journals Database [VIP] database) to find clinical trials that used bee venom acupuncture as treatment for ankle sprain. The methodological quality of randomized controlled clinical trials (RCTs) were assessed using the Cochrane Risk of Bias (RoB) tool, while non-randomized controlled clinical trials (NRCTs) were assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool.
Results: Four RCTs and one nRCT met our inclusion criteria. Almost studies showed that bee venom acupuncture has positive effect on ankle sprain. 4 studies of same intervention and control included in the meta-analysis. When comparing bee venom acupuncture and acupuncture with acupuncture, the effect size of standardized mean difference (SMD) was -0.19 (95% confidence interval [CI]: -1.95∼1.56, Z=0.55, p=0.83). And when comparing bee venom acupuncture with acupuncture, the effect size of SMD was -0.17 (95% CI: -0.65∼0.31, Z=0.71, p=0.48).
Conclusions: Although our systematic review found encouraging but limited evidence of bee venom acupuncture for ankle sprain, most of the studies included in the analysis were evaluated as methodologically high risk of bias. From now on further well-designed RCTs should be encouraged.
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KEYWORD
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Ankle sprains, Bee venom, Review, Meta-analysis
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